反应详情

5.09 g of L-tryptophan methyl ester hydrochloride are dissolved in 60 ml of methanol. 1.89 g of 35% formalin are added thereto, and the mixture is stirred at room temperature overnight. After distilling off the solvent, the resulting residue is recrystallized from methanol. 4.42 g of methyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate hydrochloride are obtained as colorless needles. Yield: 82.9%

1. distillationAfter distilling off the solvent
2. customthe resulting residue is recrystallized from methanol