Bromine → 2-Bromo-4-chloro-1-phenylbutan-1-one

HRID 1732153Notes

Reaction equation

HRID 1732153 reaction equation
[Br:1]Br.[Cl:3][CH2:4][CH2:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]>ClCCl>[Br:1][CH:6]([CH2:5][CH2:4][Cl:3])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 24408BromineHCID 2535334-Chlorobutyrophenone

Product 1

HCID 202266952-Bromo-4-chloro-1-phenylbutan-1-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bromine (10 g.) was added dropwise to a stirred solution of 4-chlorobutyrophenone (9.7 g.) in dichloromethane (25 ml.), and the mixture was stirred for a further 15 minutes, then evaporated to dryness under reduced pressure. The residue was dissolved in ethyl acetate, and the solution was washed twice with water then with brine, dried and evaporated to dryness to give α-bromo-4-chlorobutyrophenone as an oil.

Workup

  1. customevaporated to dryness under reduced pressure
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washthe solution was washed twice with water
  4. dry with materialwith brine, dried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-3324422a234642f29688b5bcf9721aec
Source dataset
uspto-grants-1986_11
Patent number
US04625036

Reaction notes

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