HCID 13753192, compound → HCID 13753189, compound

Participants

Reaction Steps

1 g of lithium aluminium hydride is added to 20 ml of absolute diethyl ether and the solution in cooled by means of an ice-bath. While stirring, a solution of 5.8 g of ethyl 2-[p-(p-fluorophenoxy)phenoxy]-propionate in 50 ml of diethyl ether is added dropwise at such a rate that the temperature does not rise above 20° C. The mixture is subsequently allowed to stir at room temperature for 1.5 hours and then cautiously poured into 100 ml of ice-cold ammonium chloride solution. The mixture is extracted twice with diethyl ether, and the extracts are washed with semi-saturated and saturated sodium chloride solution, dried over anhydrous sodium sulfate and evaporated. The yellow oily residue is distilled in a bulb-tube at 140°-142° C./0.04 Torr to yield pure 2-[p-(p-fluorophenoxy)phenoxy]-propanol.

Provenance & Evidence