HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 3,3-Bisfluoromethyl-1-bromo-butan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Fluoro-3-(fluoromethyl)-3-methylbutan-2-one | HCID 13019433 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,3-Bisfluoromethyl-1-bromo-butan-2-one | HCID 13019434 | — |
Reaction Steps
51 ml (1 mole) of bromine were added dropwise to 136 g (1 mole) of 3,3-bisfluoromethylbutan-2-one in 700 ml of methylene chloride at room temperature such that discolouration was continuous. The solvent was then distilled off under a waterpump vacuum. An almost quantitative yield of 3,3-bisfluoromethyl-1-bromo-butan-2-one was obtained as an oil, which could be further reacted directly. ##STR34##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04625066 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-36aa62a21e8f4a54a26cc1eccbe02372 |
| Source note | uspto-grants-1986_11 |