HCID 22813287, compound → HCID 22813294, compound

HRID 1732216Notes

Reaction equation

I[C@H:2]([C@H:10]1[O:31][C@H:13]2[CH2:14][C@@H:15]([C:27]([O:29][CH3:30])=[O:28])[C@@H:16](/[CH:17]=[CH:18]/[C@@H:19]([OH:26])[C@H:20]([F:25])[CH2:21][CH2:22][CH2:23][CH3:24])[C@H:12]2[CH2:11]1)[CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7].O1[C@H]2CC(C(O)=O)[C@@H](/C=C/[C@@H](O)[C@H](F)CCCC)[C@H]2C[C@H]1CCCCC(OC)=O>>[O:31]1[C@H:13]2[CH2:14][C@@H:15]([C:27]([O:29][CH3:30])=[O:28])[C@@H:16](/[CH:17]=[CH:18]/[C@@H:19]([OH:26])[C@H:20]([F:25])[CH2:21][CH2:22][CH2:23][CH3:24])[C@H:12]2[CH2:11][C@H:10]1[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7]

Participants

Reactant 2

HCID 22813287HCID 22813287, compound

HCID 22813298HCID 22813298, compound

Product 1

HCID 22813294HCID 22813294, compound

Procedure

By the procedure of Example 2, [5S,6S,8R,9S,11R,12S,15R,16R]-methyl 5-iodo-6,9-epoxy-11-carbomethoxy-16-fluoro-15-hydroxyprost-(13E)-enoate was converted to [6R,8R,9S,12S,15R,16R]-methyl 6,9-epoxy-11-carboxy-16-fluoro-15-hydroxyprost-(13E)-enoate.

Sources & evidence

ORD record: ord-f89a84bcd5ad413388e16b11f707ae68
Source dataset: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04237060

Reaction notes

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