HCID 22813268, compound → HCID 22813302, compound

Participants

Reaction Steps

To a solution of 275 mg of [6S,8R,9S,11R,12S,15R,16R]-6,9-epoxy-11-methyl-16-fluoro-15-hydroxyprost-(13E)-enoic acid in 20 ml of ethyl acetate was added 30 mg of platinum oxide. The mixture was sealed under a positive hydrogen atmosphere and vigorously stirred. After eight hours, the reaction mixture was filtered and the volatiles removed by rotary evaporation. The residual oily product was purified by chromatography over 50 g of Sephadex LH-20 using chloroform-hexane (65/35) to yield [6S,8R,9S,11R,12S,15R,16R]-6,9-epoxy-11-methyl-16-fluoro-15-hydroxyprostanoic acid.

Provenance & Evidence