反应详情

188.3 g (1.0 mole) of N-(3-dimethylaminopropyl)-3-methoxypropionamide (according to Example 13 ) are heated with 1.5 g of sodium hydroxide at 90°-110° C. in a high vacuum. Within about 30 minutes methanol is split off, vigorous forming occurring. The temperature is increased and 103 g (0.66 mole=66% of the theoretical yield) of colorless oil having a Bp0.1 of 96°-100° C. are distilled off.

1. customWithin about 30 minutes methanol is split off
2. customvigorous forming
3. temperatureThe temperature is increased
4. custom103 g (0.66 mole=66% of the theoretical yield) of colorless oil
5. customa Bp0.1 of 96°-100° C.
6. distillationare distilled off