Methanol → HCID 70511091, compound

Participants

Reaction Steps

A mixture of 5-[(2RS,3SR)-3-acetoxy-6-[(E)-2-acetoxyethylidene]-2-methyl-2-oxepanyl]-2-methyl-1-(tetrahydropyran-2-yloxy)pentane (1.2 g, 2.73 mM), methanol (10 ml) and saturated potassium carbonate (1 ml) and water (1 ml) is stirred under nitrogen at room temperature for three hours. Most of the solvent is removed in vacuo to give a thick oil. This crude material is filtered through a silica gel column (15 g) and washed with ether (100 ml). The solvent is removed in vacuo to give 5-[(2RS,3SR)-3-hydroxy-6-[(E)-2-hydroxyethylidene]-2-methyl-2-oxepanyl]-2-methyl-1-(tetrahydropyran-2-yloxy)pentane (0.953 g, 87%) as a colorless oil.

Provenance & Evidence