2-(2-Amino-4-thiazolyl)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino acetic acid, hydrochloride salt → (2-Amino-1,3-thiazol-4-YL)({[1-(diphenylmethoxy)-2-methyl-1-oxopropan-2-YL]oxy}imino)acetic acid

HRID 1732290Notes

Reaction equation

HRID 1732290 reaction equation
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[N:12][O:13][C:14]([C:17]([O:19][CH:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:18])([CH3:16])[CH3:15])[C:9]([OH:11])=[O:10])[N:7]=1>O>[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[N:12][O:13][C:14]([C:17]([O:19][CH:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[O:18])([CH3:16])[CH3:15])[C:9]([OH:11])=[O:10])[N:7]=1

Participants

3

Reactant 1

HCID 898850052-(2-Amino-4-thiazolyl)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino acetic acid, hydrochloride salt

Product 1

HCID 53674735(2-Amino-1,3-thiazol-4-YL)({[1-(diphenylmethoxy)-2-methyl-1-oxopropan-2-YL]oxy}imino)acetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of the hydrochloride salt product from part (e) in water (20 ml./g.) is adjusted to pH 2.6 and stirred for 30 minutes at 0°. The resulting suspension is filtered, washed thoroughly with water, and dried to yield 2-(2-amino-4-thiazolyl)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)iminoacetic acid.

Workup

  1. filtrationThe resulting suspension is filtered
  2. washwashed thoroughly with water
  3. customdried

Sources & evidence

ORD record
ord-c10006c316754e7cbd3b5f6d41acb96a
Source dataset
uspto-grants-1980_12
Patent number
US04237128

Reaction notes

Loading…