2-Amino-4-phenylthiazole → HCID 13466428, compound

Participants

Reaction Conditions

Reaction Steps

17.6 g of 2-amino-4-phenylthiazole are dissolved in 100 ml of tetrahydrofuran, the resulting solution is cooled to approximately 15° C. and 17.5 g of acetylene dicarboxylic acid diethyl ester are slowly added to it with stirring at that temperature. The mixture is left standing for 3 days, after which the crystals formed are filtered off the quantity of which was increased by concentrating the mother liquor to approximately half its original volume and recrystallized from ethanol. 3-Phenyl-7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester is thus obtained in a yield of 16.9 g, corresponding to 56.3% of the theoretical.

Provenance & Evidence