Diethyl acetylenedicarboxylate → HCID 70592354, compound

HRID 1732298Notes

Reaction equation

HRID 1732298 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:14])=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=2)[N:6]=1.[CH2:15]([O:17][C:18]([C:20]#[C:21][C:22](OCC)=[O:23])=[O:19])[CH3:16]>>[CH2:15]([O:17][C:18]([C:20]1[N:6]2[C:5]([C:7]3[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=3)=[C:4]([CH3:14])[S:3][C:2]2=[N:1][C:22](=[O:23])[CH:21]=1)=[O:19])[CH3:16]

Participants

3

Reactant 2

HCID 69803Diethyl acetylenedicarboxylateHCID 7169804-(4-Bromophenyl)-5-methyl-1,3-thiazol-2-amine

Product 1

HCID 70592354HCID 70592354, compound

Procedure

The procedure is as in Example 1, except that 9.4 g of 2-amino-4-(p-bromophenyl)-5-methyl thiazole and 5.95 g of acetylene dicarboxylic acid diethyl ester are used. 2-methyl-3-(p-Bromophenyl)-7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester melting at 217° to 220° C. (decomposition) is obtained.

Sources & evidence

ORD record
ord-27fe03aca00a49c5b8d6c06b8597c727
Source dataset
uspto-grants-1980_12
Patent number
US04237136

Reaction notes

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