Dimethyl acetylenedicarboxylate → HCID 54181417, compound

Participants

Reaction Steps

100 ml of tetrahydrofuran are added to 10.1 g of 2-amino-1,3,4-thiadiazole, followed by the gradual introduction of 14.2 g of acetylene dicarboxylic acid dimethyl ester. The reaction mixture is left standing for 3 days, resulting in the formation of a clear, yellow colored solution. The solution thus formed is concentrated by evaporation in vacuo to dryness. Recrystallization of the residue from ethyl acetate gives 7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid methyl ester melting at 134° C. with decomposition.

Provenance & Evidence