Ethanol → HCID 53873377, compound

Participants

Reaction Steps

The reaction of 9.7 g of 2-amino-5-(3', 4', 5'-trimethoxyphenyl)-1,3,4-thiadiazole with 6.2 g of acetylene dicarboxylic acid dimethyl ester in 200 ml of ethanol in accordance with Example 12 gives 2-(3',4',5'-trimethoxyphenyl)-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester which, as a crude product, melts at 205°-207° C. with decomposition and which is converted as described in Example 12 into the corresponding free acid melting at 220°-223° C. with decomposition.

Provenance & Evidence