Diethyl acetylenedicarboxylate → HCID 53970052, compound

Participants

Reaction Steps

8.1 g of 2-amino-5-(β-phenylethyl)-1,3,4-thiadiazole are heated with 6.8 g of acetylene dicarboxylic acid diethyl ester in 100 ml of ethanol until a clear solution has formed. After standing overnight, the solution is concentrated by evaporation to dryness. The residue crystallises on triturating with ether. 2-(β-Phenylethyl)-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester melting at 95° to 98° C. is thus obtained.

Provenance & Evidence