2-Aminothiazole → HCID 57266412, compound

Participants

Reaction Steps

10 g of 2-aminothiazole are dissolved in 150 ml of absolute ethanol and 19.8 g of acetylene dicarboxylic acid di-n-propyl ester are added to the resulting solution. The mixture is heated to 50° to 60° C. for 10 minutes. After standing overnight at room temperature the precipitate is filtered off, washed with ether and dried in vacuo. 7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid n-propyl ester melting at 154°-156° C. with decomposition is thus obtained in a yield of 14.5 g (61% of the theoretical).

Provenance & Evidence