Diethyl acetylenedicarboxylate → HCID 13466426, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.5 g of 2-amino-5-(p-chlorophenyl)-1,3,4-thiadiazole, 100 ml of absolute ethanol and 4.5 g of acetylene dicarboxylic acid diethyl ester is heated to about 50° C. until a clear solution has formed and then left standing for 2 days. The product is filtered off, washed with ethanol and dried. Thus 2-(p-chlorophenyl)-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester melting at 220°-222° C. with decomposition is obtained in a yield of 3.5 g (40.2% of the theoretical).

Provenance & Evidence