Diethyl acetylenedicarboxylate → HCID 53656289, compound

Participants

Reaction Steps

A mixture of 3.4 g 2-amino-5-methylthiazole, 70 ml of ethanol and 5.1 g of acetylene dicarboxylic acid diethyl ester is left standing for 3 days. The solution is evaporated to dryness and the residue is triturated with ethyl acetate, crystallization occurring. The product is filtered off under suction, washed with ether and dried. The 2-methyl-7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid ethyl ester thus obtained in a yield of 4.5 g (63% of the theoretical) melts at 119°-121° C.

Provenance & Evidence