HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14022367, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| Reactant | 4-(2-Methoxypropoxy)piperidine | HCID 14022392 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 14022367 | HCID 14022367 | 45.1% |
Reaction Steps
4-Amino-2-chloro-6,7-dimethoxyquinazoline (3.6 g.), 4-(2-methoxy-n-propoxy)piperidine (3.0 g.) and triethylamine (1.5 g.) in n-butanol were heated under reflux for 30 hours. The solvent was evaporated in vacuo, the residue stirred with diethyl ether, the solid collected and recrystallized twice from isopropanol to give 4-amino-6,7-dimethoxy-2-[4-(2-methoxy-n-propoxy)piperidino]quinazoline hydrochloride (2.8 g.), m.p. 239°-241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04237138 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-e4b3b8abecd54975ae9110d4ed7aab41 |
| Source note | uspto-grants-1980_12 |