Hydrochloric Acid → 4-(2-Methoxyethoxy)piperidine

A solution of N-acetyl-4-hydroxypiperidine (30.5 g.) in dimethylformamide (200 ml.) was added dropwise to a stirred suspension of sodium hydride (11.26 g., 50% dispersion in mineral oil) in dimethylformamide (300 ml.) under an atmosphere of nitrogen. The reaction temperature was kept below 30° C. by external cooling and, after the addition was complete, stirring was continued for a further 11/4 hours. A solution of 1-bromo-2-methoxyethane (32.6 g.) in dimethylformamide (100 ml.) was then added dropwise with external cooling, and the resulting clear solution was stirred at room temperature overnight. The reaction mixture was then evaporated in vacuo, the residue partitioned between water and chloroform, the organic extracts dried (Na2SO4) and evaporated to leave a crude residue (16.1 g.). The above aqueous phase was saturated with sodium chloride, further extracted with chloroform, and the organic phase was dried (Na2SO4), and evaporated to leave a further residue (9.2 g.). This residue was combined with the original residue and heated on a steam bath overnight with hydrochloric acid (243 ml., 2N). The reaction mixture was extracted with chloroform to remove residual mineral oil, the aqueous phase concentrated, basified with sodium hydroxide (pH 12), then reextracted with chloroform. The organic extracts were washed with brine, dried (Na2SO4) and evaporated to leave 4-(2-methoxyethoxy)piperidine (8.3 g.). A sample of this product in ethyl acetate was converted to the oxalate salt by the addition of ethereal oxalic acid followed by recrystallization from ethanol, the oxalate having an m.p. of 86°-88° C.

1. customwas kept below 30° C.
2. temperatureby external cooling
3. additionafter the addition
4. custom4 hours
5. stirringthe resulting clear solution was stirred at room temperature overnight
6. customThe reaction mixture was then evaporated in vacuo
7. customthe residue partitioned between water and chloroform
8. dry with materialthe organic extracts dried (Na2SO4)
9. customevaporated
10. customto leave a crude residue (16.1 g.)
11. extractionfurther extracted with chloroform
12. dry with materialthe organic phase was dried (Na2SO4)
13. customevaporated
14. customto leave a further residue (9.2 g.)
15. extractionThe reaction mixture was extracted with chloroform
16. customto remove residual mineral oil
17. concentrationthe aqueous phase concentrated
18. washThe organic extracts were washed with brine
19. dry with materialdried (Na2SO4)
20. customevaporated

ORD record

ord-ecc2c085e1d04a748cbd99556a62acb2

Source dataset

uspto-grants-1980_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04237138