Methyl di-t-butyl hydroxyhydrocinnamate → HCID 20306448, compound

Participants

Reaction Steps

A mixture of 2.9 g of 3,8-bis(2-hydroxyethyl)-7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro [4.5]decane, 6.4 g of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 0.3 g of sodium methoxide was refluxed for 8 hours in 300 ml of xylene, while removing 250 ml of xylene together with methanol formed in situ. After completion of the reaction, xylene was evaporated from the reaction under reduced pressure and the resulting residue was recrystallized from ligroin, giving the desired compound in the form of white crystals melting at 178°-179° C.

Provenance & Evidence