Lithium amide → HCID 20306454, compound

Participants

Reaction Steps

A mixture of 20 g of 2,2,4,4,14,14,16,16-octamethyl-3,15-bis(2-hydroxyethyl)-7,11,18,21-tetraoxa-3,15-diazatrispiro[5.2.2.5.2.2]heneicosane, 26 g of methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate and 2 g of lithium amide was refluxed for 8 hours in 400 ml of toluene under argon stream. Following the procedures in Example 1, the residue was purified first by column chromatography through silica gel with a 9:1 by volume mixture of benzene and ethyl acetate, then by recrystallization from a 4:1 by volume mixture of n-hexane and benzene, giving the desired compound in the form of pale yellow crystals melting at 176°-178° C.

Provenance & Evidence