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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1732428Generated: October 26, 2026

Acetic Anhydride → Pseudoephedrine Hydrochloride

https://huagongshe.com/reaction/1732428

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AnhydrideHCID 7918—
ReactantEphedrine HydrochlorideHCID 65326—
ProductPseudoephedrine HydrochlorideHCID 9581—

Reaction Steps

It has also been reported that the reaction of 1-ephedrine hydrochloride with 10 moles excess acetic anhydride gave d-pseudoephedrine hydrochloride. No yields were reported. Schmidt and Calliess, Arch. Pharm., 250, 154 (1912).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04237304
Source datasetuspto-grants-1980_12
ORD IDord-8016b3e9da5c4d3b97578994cfdd3b91
Source noteuspto-grants-1980_12