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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1732429Generated: October 25, 2026

DL-Ephedrine → Pseudoephedrine

https://huagongshe.com/reaction/1732429

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDL-EphedrineHCID 5032—
Reactant2-Methylbenzoyl chlorideHCID 70276—
ProductPseudoephedrineHCID 7028—

Reaction Steps

It was also reported that the reaction of 1-ephedrine with o-methylbenzoyl chloride and subsequent hydrolysis of the resulting amide gave d-pseudoephedrine. Welsh, J. Am. Chem. Soc., 71, 3500 (1949).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04237304
Source datasetuspto-grants-1980_12
ORD IDord-536a66a25795420dbf3e52e847479fdb
Source noteuspto-grants-1980_12