Hydrochloric Acid → HCID 20306486, compound

Participants

Reaction Conditions

Reaction Steps

Methyl α-methylthio(p-dimethylaminophenyl)acetate (1.215 g) was dissolved in 20 ml of methanol, and 30 ml of a 10% aqueous solution of sodium hydroxide was added. The mixture was stirred at 70° C. for 14 hours. The mixture was acidified to a pH of 5 with conc. hydrochloric acid, and continuously extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to afford 0.951 g of α-methylthio(p-dimethylaminophenyl)acetic acid in a yield of 83%.

Provenance & Evidence