Potassium Hydroxide → HCID 54394348, compound

HRID 1732467Notes

Reaction equation

HRID 1732467 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([O:21]C(=O)C)=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:25]=1)=[O:4].[OH-].[K+]>CO.O>[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:25]=1)=[O:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 53698142HCID 53698142, compound

Product 1

HCID 54394348HCID 54394348, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

1.0 Gm. of the acetate derivative obtained in Example 15 is heated with a 10 ml. 50% methanol-water solution of 0.5 g. of potassium hydroxide for one hour. After evaporation of the methanol in vacuo the reaction mixture is acidified with glacial acetic acid. The resultant solids are removed by filtration, washed with water and dried to yield 2-(methoxycarbonylamino) 6-(p-hydroxyphenylthio) imidazo [1,2-a] pyridine.

Workup

  1. customAfter evaporation of the methanol in vacuo the reaction mixture
  2. customThe resultant solids are removed by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-b92df12d43be428594532fe30a7dd20a
Source dataset
uspto-grants-1980_12
Patent number
US04237300

Reaction notes

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