Ammonia → Z-Lys(boc)-NH2

Participants

Reaction Steps

A stream of NH3 was passed over a solution of Z-Lys(Boc)ONp (10.2 g, 2.0 mmole, Bachem) in THF (200 ml) for about 3 hr. A precipitate formed. The solvent was removed and the residue triturated and thoroughly washed with ether. The dried protected amide weighed 5.8 g (75%), m.p. 140°-142°, [α]D24 +1.9° (c 1.3. DMF): RfB, 0.54; RfG, 0.54.

Provenance & Evidence