1-Hydroxybenzotriazole → HCID 131711962, compound

Participants

Reaction Steps

A sample of compound XV (4.3 g, 9 mmole) was hydrogenated as described in the previous paragraph and the partially deblocked peptide (RfC, 0.60) was acylated with Z-L-Ala-ONp (3.47 g, 10 mmole, Bachem) in the presence of DIEA (3.2 ml, 20 mmole) and HOBt (1.3 g, 9 mmole). The product isolated as described for XV weighed 4.2 g (85%) m.p. 214°-217° C., [α]D24 -9.5° (c 0.8, DMF); RfB, 0.48; RfI, 0.33.

Provenance & Evidence