Diisopropylethylamine → HCID 54013482, compound

Participants

Reaction Steps

A solution of L-valine tert-butyl ester hydrochloride (2.1 g, 10 mmole) in DMF (10 ml) was treated with DIEA (1.6 ml. 10 mmole) and benzyloxycarbonyl-L-alanine p-nitrophenyl ester (3.5 g, 10 mmole). After overnight at room temperature, the solution was filtered through a column of neutral Al2O3 (100 g) and eluted with DMF. The solvent was removed in vacuo and the residue filtered through a column of silica gel (50 g) eluted with CHCl3. The resulting oil (3.0 g, 79%) was homogeneous on tlc; Rf (CHCl3) 0.10; Rf (ether) 0.70; Rf (CHCl3 24, CH3OH 1) 0.55.

Provenance & Evidence