反应详情

A solution of 2-(4-bromobutyl)benzofuran-6-carboxylic acid (29.7 g., 0.1 mole) and sulfuric acid (0.5 ml.) in ethanol (200 ml.) is boiled under reflux. The solution is concentrated to 7/8 volume at reduced pressure. The residue is poured into water. The oily ester is extracted with ether. Evaporation of the solvent provides ethyl 2-(4-bromobutyl)benzofuran-6-carboxylate.

1. temperatureunder reflux
2. concentrationThe solution is concentrated to 7/8 volume at reduced pressure
3. additionThe residue is poured into water
4. extractionThe oily ester is extracted with ether
5. customEvaporation of the solvent