HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → N,N-dimethyl-2-(4-aminobutyl)benzofuran-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl 2-(4-aminobutyl)benzofuran-6-carboxylate | HCID 20303943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N,N-dimethyl-2-(4-aminobutyl)benzofuran-6-carboxamide | HCID 20303938 | — |
Reaction Steps
A solution of ethyl 2-(4-aminobutyl)benzofuran-6-carboxylate (13.0 g., 0.05 mole), dimethylamine (35 g.), and a catalytic amount of sodium ethoxide (approximately 100 mg.) in ethanol (100 ml.) is heated in a sealed pressure bottle at 65° C. for 18 hours. Evaporation of the solvent provides N,N-dimethyl-2-(4-aminobutyl)benzofuran-6-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04238487 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-6952d2c5160e4893bf721c97ac9a59b0 |
| Source note | uspto-grants-1980_12 |