HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl Isothiocyanate → N-[2-(6-dimethylaminomethyl-2-benzofuranylmethylthio)ethyl]-N'-(2-propenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl Isothiocyanate | HCID 5971 | — |
| Reactant | 2-(2-Aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran | HCID 20303964 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[2-(6-dimethylaminomethyl-2-benzofuranylmethylthio)ethyl]-N'-(2-propenyl)thiourea | HCID 20303954 | — |
Reaction Steps
A solution of 2-(2-aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran (Example 1, Step E) (2.6 g., 0.01 mole) and allyl isothiocyanate (1.1 g., 0.011 mole) in acetonitrile (15 ml.) is kept at 25°-27° C. for 16 hours. The solvent is evaporated and the residual oil chromatographed (silica gel/5% methanol in chloroform) to yield N-[2-(6-dimethylaminomethyl-2-benzofuranylmethylthio)ethyl]-N'-(2-propenyl)thiourea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04238487 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-83a720232473431aa1fbe6110f92cfbf |
| Source note | uspto-grants-1980_12 |