HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran → HCID 178483158, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran | HCID 20303964 | — |
| Reactant | N-Nitro-S-methylisothiourea | HCID 135927615 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178483158 | HCID 178483158 | — |
Reaction Steps
A solution of 2-(2-aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran (Example 1, Step E) (2.6 g., 0.01 mole) and S-methyl-N-nitroisothiourea (1.4 g., 0.01 mole) in acetonitrile (15 ml.) is kept at 25°-27° C. for 4 hours. The solvent is evaporated and the residue chromatographed on silica gel (5% methanol in chloroform elution) to yield N-[2-(6-dimethylaminomethyl-2-benzofuranylmethylthio)ethyl]-N'-nitroguanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04238487 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-937b1c673aaf4eec8bc9d641616ec0a5 |
| Source note | uspto-grants-1980_12 |