Methanol → HCID 53870194, compound

Participants

Reaction Steps

A solution of 2-(2-aminoethylthiomethyl)-6-(dimethylaminomethyl)benzofuran (Example 1, Step E) (2.6 g., 0.01 mole) and methanesulfonyliminodithiocarbonic acid dimethyl ester (2.0 g., 0.01 mole) in methanol (15 ml.) is kept at 25°-27° C. for 4 hours. A solution of 10 g. of methylamine in 35 ml. of methanol is added and the resulting solution is kept at 25°-27° C. for 16 hours. The solvent is evaporated to leave N-[2-(6-dimethylaminomethyl-2-benzofuranylmethylthio)-ethyl]-N'-methanesulfonyl-N"-methylguanidine as a residual oil which is purified by column chromatography (silica gel/5% methanol in chloroform).

Provenance & Evidence