4-Methylmorpholine → N,N'-Dicyclohexylurea

Participants

Reaction Steps

0.05 ml of N-methylmorpholine and 100 mg of DCCI are added, at -5°, to a solution of 470 mg of Z-Asn-Phe-Phe-[D-Trp(F) -Lys(Boc)-Thr(But)-Phe-OH, 165 mg of H-Gaba-OBzl p-toluenesulphonate (Example 1.7A) and 66 mg of N-hydroxybenzotriazole in 2 ml of dimethylformamide. After 16 hours at this temperature, the reaction mixture is worked up analogously to Example 7.1. Except for traces of dicyclohexylurea, the product is obtained in the pure form.

Provenance & Evidence