HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 1H-PYRROL-2-AMINE, N-[2-[[(5-METHYL-1H-IMIDAZOL-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| Reactant | 2-Methylsulphinyl-3-nitropyrrole | HCID 13059516 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1H-PYRROL-2-AMINE, N-[2-[[(5-METHYL-1H-IMIDAZOL- | HCID 13646622 | 34.1% |
Reaction Steps
A solution of 2-methylsulphinyl-3-nitropyrrole (2g, 0.01 mol) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (2g, 0.01 mol) in methanol (50 ml) was refluxed for 7 days and evaporated to dryness. The residue was chromatographed on a silica gel column eluted with ethyl acetate, and the eluate was evaporated to dryness and recrystallised from propan-2-ol to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-3-nitropyrrole (0.96g, 31%) m.p. 161-162°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04238494 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-b56642d7fde842e685b7e5658215b0b2 |
| Source note | uspto-grants-1980_12 |