Sodium Methoxide → 4-Benzyl-2-(methylsulfanyl)-3-nitro-1H-pyrrole

Participants

Reaction Steps

A solution of sodium methoxide (sodium (1.9g, 0.084 mol) dissolved in methanol (100 ml)) and a solution of 1-amino-3-phenylpropan-2-one hydrochloride (7.9g, 0.042 mol) in methanol (100 ml) were simultaneously added dropwise, to a stirred solution of 1-nitro-2-methylthio-2-methylsulphinyl-ethylene (7.7g, 0.042 mol) in methanol. The temperature was maintained at about 60° during the addition, which took 25 minutes. The solvent was then removed in vacuo, and the residual dark red oil was chromatographed on a silica gel column. Elution and recrystallisation with petroleum ether/ethyl acetate (7:3) gave 2-methylthio-3-nitro-4-benzylpyrrole (2.95g, 28.5%) m.p. 190-192.5°.

Provenance & Evidence