Thionyl Chloride → HCID 20304082, compound

HRID 1732630Notes

Reaction equation

HRID 1732630 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][CH2:14][CH2:13]2)O.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:10]1[CH:11]=[C:12]2[C:16](=[CH:17][CH:18]=1)[CH2:15][CH2:14][CH2:13]2)[Cl:21]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 20304048HCID 20304048, compound

Product 1

HCID 20304082HCID 20304082, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

79.3 g (0.26 mol) of 2-chlorophenyl-indan-5-yl-carbinol, dissolved in 150 ml of benzene, are added dropwise to a mixture of 21.5 ml (0.26 mol) of thionyl chloride and 150 ml of benzene at 70° C. After heating the reaction mixture under reflux for five hours, it is evaporated. 71 g (98% of theory) of 2-chlorophenyl-indan-5-yl-chloromethane of refractive index nD20 =1.6050 are obtained. ##STR11##

Workup

  1. temperatureAfter heating the reaction mixture
  2. temperatureunder reflux for five hours
  3. customit is evaporated

Sources & evidence

ORD record
ord-cf795f077be2495f87d24ba4afc89810
Source dataset
uspto-grants-1980_12
Patent number
US04238498

Reaction notes

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