Imidazole → HCID 20304051, compound

HRID 1732631Notes

Reaction equation

HRID 1732631 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH2:15][CH2:14][CH2:13]2)Cl.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>ClC1C=CC=CC=1Cl.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH2:16][CH2:15][CH2:14][CH2:13]2

Participants

5

Reactant 2

HCID 795ImidazoleHCID 20304071HCID 20304071, compound

Product 1

HCID 20304051HCID 20304051, compoundYield 55.3%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 72391,2-DichlorobenzeneSolvent2×

Conditions

Temperature
180 °C

Procedure

44 g (0.15 mol) of 2-chlorophenyl-1,2,3,4-tetrahydronaphth-6-yl-chloromethane, dissolved in 50 ml of 1,2-dichlorobenzene, are added dropwise to a suspension of 51 g (0.75 mol) of imidazole in 100 ml of 1,2-dichlorobenzene at 180° C. The reaction mixture is heated to 180° C. for 2 hours and, after cooling, is poured onto water and the organic phase is diluted with methylene chloride and washed with water. After drying the solution over sodium sulphate, it is evaporated in vacuo. 26.8 g (55% of theory) of 2-chlorophenyl-imidazol-1-yl-1,2,3,4-tetrahydronaphth-6-yl-methane of refractive index nD20 =1.6000 are obtained.

Workup

  1. temperatureafter cooling
  2. additionis poured onto water
  3. washwashed with water
  4. dry with materialAfter drying the solution over sodium sulphate, it
  5. customis evaporated in vacuo

Sources & evidence

ORD record
ord-89cc97b3d3a74892a59df06355fdf97f
Source dataset
uspto-grants-1980_12
Patent number
US04238498

Reaction notes

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