5-Chloro-2-methoxybenzoyl chloride → HCID 20304342, compound

HRID 1732655Notes

Reaction equation

HRID 1732655 reaction equation
Cl.[NH2:2][CH:3]([CH3:18])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]([O:15]CC)=[O:14])=[CH:7][CH:6]=1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25](Cl)=[O:26]>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25]([NH:2][CH:3]([CH3:18])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:9][CH:10]=1)=[O:26]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20304458Ethyl 3-[4-(2-aminopropyl)phenyl]propanoate--hydrogen chloride (1/1)

Product 1

HCID 20304342HCID 20304342, compound

Procedure

By the reaction of ethyl β-[4-(2-aminopropyl)-phenyl]-propionate hydrochloride (m.p. 115°-117° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained β-{4-[2-(5-chloro-2-methoxybenzamido)-propyl]-phenyl}-propionic acid; m.p. 125°-126° C., after recrystallization from isopropanol/water.

Sources & evidence

ORD record
ord-23f80bda14894900ae66ecd15d503dcd
Source dataset
uspto-grants-1980_12
Patent number
US04238506

Reaction notes

Loading…