5-Chloro-2-methoxybenzoyl chloride → HCID 20304403, compound

HRID 1732658Notes

Reaction equation

HRID 1732658 reaction equation
Cl.[CH3:2][NH:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]([O:16]CC)=[O:15])=[CH:8][CH:7]=1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25](Cl)=[O:26]>>[CH3:2][N:3]([CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)[C:25](=[O:26])[C:24]1[CH:28]=[C:20]([Cl:19])[CH:21]=[CH:22][C:23]=1[O:29][CH3:30]

Participants

3

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20304413HCID 20304413, compound

Product 1

HCID 20304403HCID 20304403, compound

Procedure

By the reaction of ethyl β-{4-[2-(N-methylamino)-ethyl]-phenyl}-propionate hydrochloride (m.p. 162°-164° C.) with 5-chloro-2-methoxybenzoyl chloride, there is obtained β-{4-[2-(N-methyl-5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid; m.p. 152°-153° C., after recrystallization from toluene.

Sources & evidence

ORD record
ord-9b56a61b860345449b4adb679a4420d8
Source dataset
uspto-grants-1980_12
Patent number
US04238506

Reaction notes

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