HCID 12725565, compound → HCID 9989769, compound

Participants

Reaction Steps

5-Acetyl-6-hydroxy-1,2,3,4-tetrahydronaphthalene (15.0 g) was heated at reflux in a mixture of dioxan (40 ml) and 50% HCl (50 ml) containing zinc amalgam (16.0 g) for 18 hours. The mixture was cooled, filtered and the filtrate was extracted with ether. The ether extracts were washed with water, dried (MgSO4), filtered and evaporated to dryness leaving a solid which crystallised from petroleum ether (60°-80°) to give 5-ethyl-6-hydroxy-1,2,3,4-tetrahydronaphthalene as pale yellow needles, 13.5 g (97%), mp 94°-5°.

Provenance & Evidence