Chloroform → 7-Trifluoromethyl-8,10-dichloro-10,11-dihydrodibenzo(b,f)thiepine

Participants

Reaction Steps

A mixture of the alcohol from the preceding experiment (3.3 g) and thionyl chloride (1.2 ml) is allowed to stand at room temperature for 12 hours and then heated under a reflux condenser in a steam-bath for 1 hour. The reaction mixture is cooled, dissolved in chloroform and the solution washed with water and dried over calcium chloride. Evaporation of the solvent affords crystalline 7-trifluoromethyl-8,10-dichloro-10,11-dihydrodibenzo(b,f)thiepine, melting at 100°-102° C. after crystallization from acetone.

Provenance & Evidence