Water → 2-(4-Chloro-3-methoxyphenylthio)-4-methoxybenzyl chloride

Participants

Reaction Steps

Thionyl chloride (40.5 g) is added dropwise at 10°-20° C. to a stirred solution of the alcohol from the preceding experiment (91 g) in pyridine (30 ml) and chloroform (30 ml) in the course of 1 hour. The mixture is stirred at room temperature for an additional hour, set aside for 48 hours, heated to 40° C. for 2 hours and decomposed with water. The product is isolated by extraction with benzene. The extract affords 86 g of crude oily 2-(4-chloro-3-methoxyphenylthio)-4-methoxybenzyl chloride which is used without purification in the next step.

Provenance & Evidence