Methanol → HCID 13567453, compound

HRID 1732830Notes

Reaction equation

HRID 1732830 reaction equation
[OH:1][C:2]1[C:12]2[N:11]=[CH:10][CH:9]3[CH2:13][CH2:14][CH2:15][N:8]3[C:7](=[O:16])[C:6]=2[CH:5]=[CH:4][C:3]=1[CH3:17].[CH3:18][OH:19]>>[OH:1][C:2]1[C:12]2[NH:11][CH:10]([O:19][CH3:18])[CH:9]3[CH2:13][CH2:14][CH2:15][N:8]3[C:7](=[O:16])[C:6]=2[CH:5]=[CH:4][C:3]=1[CH3:17]

Participants

3

Reactant 2

HCID 887MethanolHCID 13567463HCID 13567463, compound

Product 1

HCID 13567453HCID 13567453, compound

Procedure

5.5 mg of 2,3,5,11a-tetrahydro-9-hydroxy-8-methyl-1H-pyrrolo(2,1-C)(1,4)benzodiazepin-5-one was dissolved in 0.2 ml of hot methanol and allowed to stand at -20° C. for 3 days. Thus, 3.0 mg of 2,3,5,10,11,11a-hexahydro-9-hydroxy-11-methoxy-8-methyl-1H-pyrrolo(2,1-C)(1,4)benzodiazepin-5-one was obtained as a colorless crystal. Its infrared absorption spectrum just coincided with that of the product of Example 4.

Sources & evidence

ORD record
ord-12d89e6401bc4b7f9b1e8fe991bc16f1
Source dataset
uspto-grants-1980_12
Patent number
US04239683

Reaction notes

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