Acetonitrile → (1-Aminoethylidene)bisphosphonic acid

Participants

Reaction Steps

Into a reactor like the above were charged 130.5 g phosphorous acid and 69 g Sulfolane-W (tetramethylene sulfone, Shell Chemical Co.). 31.2 g acetonitrile was introduced slowly for 11/2 hours at 140°-150° C. and the reactants were held for additional 81/2 hours at 153°-158° C. The 1-aminoethane-1, 1-diphosphonic acid produced was isolated from the reaction mixture in the manner described in Example 1. The yield was 75% of the theory on the acetonitrile employed.

Provenance & Evidence