Sodium Hydroxide → 4-Carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetic acid

HRID 1732851Notes

Reaction equation

[C:1]([C:4]1([CH3:22])[C:11]2[C:7](=[C:8]([CH3:19])[N:9]([CH2:13][C:14]([O:16]CC)=[O:15])[C:10]=2[CH3:12])[C:6]([CH3:21])([CH3:20])[CH2:5]1)(=[O:3])[NH2:2].[OH-].[Na+]>>[C:1]([C:4]1([CH3:22])[C:11]2[C:7](=[C:8]([CH3:19])[N:9]([CH2:13][C:14]([OH:16])=[O:15])[C:10]=2[CH3:12])[C:6]([CH3:21])([CH3:20])[CH2:5]1)(=[O:3])[NH2:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 12894334Ethyl 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetate

Product 1

HCID 234562094-Carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetic acid

Procedure

Reaction of the ethyl 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetate described above in Example 20AC with alcoholic sodium hydroxide and isolation of the product from an acid or neutral medium affords 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetic acid.

Sources & evidence

ORD record: ord-9e8d9580e0c541438dc3690dbd2bbf85
Source dataset: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04239687

Reaction notes

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