3,4,5-Trimethoxybenzyl alcohol → 3,4,5-Trimethoxybenzaldehyde

HRID 1732854Notes

Reaction equation

HRID 1732854 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[CH2:6][OH:7]>C(O)(=O)C.O>[CH3:14][O:13][C:9]1[CH:8]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7]

Participants

4

Reactant 1

HCID 774493,4,5-Trimethoxybenzyl alcohol

Product 1

HCID 68583,4,5-Trimethoxybenzaldehyde

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

To this oxydation mixture, g 19.8 of 3,4,5-trimethoxy benzyl alcohol dissolved in 160 ml of glacial acetic acid are very slowly added under continuous stirring. The mixture is kept reacting during 30' after the end of the addition and is then cooled, diluted with water and extracted with CHCl3 (3 fractions of 200 ml each).

Workup

  1. additionare very slowly added under continuous stirring
  2. additionafter the end of the addition
  3. temperatureis then cooled
  4. extractionextracted with CHCl3 (3 fractions of 200 ml each)

Sources & evidence

ORD record
ord-0a73c93a88044b1e901bdae4ee32b15e
Source dataset
uspto-grants-1980_12
Patent number
US04239702

Reaction notes

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