反应详情

A solution of 2,3-dichloro-4-nitroaniline (25 g) and sodium methoxide (25 g) in methanol (250 ml) is stirred and heated at reflux under a nitrogen atmosphere for 5.5 hours. The reaction mixture is poured into water (1.5 l), the precipitated yellow solid is collected and dried. This material is purified by chromatography on silica gel using 1:1 hexane/ether eluent. The eluents are collected and evaporated to dryness to afford 13 g of title compound, m.p. 118°-123° C.

1. temperatureheated
2. temperatureat reflux under a nitrogen atmosphere for 5.5 hours
3. customthe precipitated yellow solid is collected
4. customdried
5. customThis material is purified by chromatography on silica gel using 1:1 hexane/ether eluent
6. customThe eluents are collected
7. customevaporated to dryness