L-Lysine → Lysine 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetate

Participants

Reaction Steps

33.1 g 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetic acid and 150 ml ethanol were added at about 40° C. to a solution of 14.6 g of L (-)-lysine in 200 ml anhydrous ethanol. Using the method of Example 1, there was precipitated a salt with melting point 226° C. Again the infra-red spectrum showed than addition salt was formed. A solution of 2.5 g product salt in 100 ml water had a pH of 6.2.

Provenance & Evidence