HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 825289, compound → 1-[(Thiophen-2-yl)methyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 825289 | HCID 825289 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-[(Thiophen-2-yl)methyl]pyrrolidine | HCID 12788070 | — |
Reaction Steps
Lithium aluminium hydride (9.6 g) was added to N-(2-thienylcarbonyl)pyrrolidine (35.4 g) in ether. After 41/2 hr the reaction was quenched with water and extracted with chloroform. Evaporation of the organic extracts gave an oil which was distilled under reduced pressure (21.5 g) b.p. 60°-70° (10-16 mm). TLC silica/ethyl acetate, methanol, Rf 0.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239769 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-b3532bd6079843e5895a0b19a1fd55c3 |
| Source note | uspto-grants-1980_12 |